Yuen, Fung Ping : rechercher sur Z-Library

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1

SARS-CoV-2 and COVID-19: The most important research questions

Yuen, Kit-San, Ye, Zi -Wei, Fung, Sin-Yee, Chan, Chi-Ping, Jin, Dong-Yan

Journal:

Cell & Bioscience

Année:

2020

Langue:

english

Fichier:

PDF, 847 KB

english, 2020

2

Separation, structure characterization, conformation and immunomodulating effect of a hyperbranched heteroglycan from Radix Astragali

Jun-Yi Yin, Ben Chung-Lap Chan, Hua Yu, Iris Yuen-Kam Lau, Xiao-Qiang Han, Sau-Wan Cheng, Chun-Kwok Wong, Clara Bik-San Lau, Ming-Yong Xie, Kwok-Pui Fung, Ping-Chung Leung, Quan-Bin Han

Journal:

Carbohydrate Polymers

Année:

2012

Langue:

english

Fichier:

PDF, 875 KB

english, 2012

3

A Randomized Controlled Trial of Auricular Transcutaneous Electrical Nerve Stimulation for Managing Posthysterectomy Pain

Tsang, Hin Cheung, Lam, Chi Shan, Chu, Ping Wing, Yap, Jacqueline, Fung, Tak Yuen, Cheing, Gladys L. Y.

Journal:

Evidence-based Complementary and Alternative Medicine

Année:

2011

Langue:

english

Fichier:

PDF, 417 KB

english, 2011

4

The use of atorvastatin for chronic subdural haematoma: a retrospective cohort comparison study *

Chan, David Yuen Chung, Chan, Danny Tat Ming, Sun, Tin Fung David, Ng, Stephanie Chi Ping, Wong, George Kwok Chu, Poon, Wai Sang

Journal:

British Journal of Neurosurgery

Année:

2016

Langue:

english

Fichier:

PDF, 1.10 MB

english, 2016

5

An innovative anti-cancer Chinese herbal formula exhibited multi-targeted efficacies in metastatic breast cancer mouse model

Yue, Grace Gar-Lee, Lee, Julia Kin-Ming, Chan, Ben Chung-Lap, Kwok, Hin-Fai, Hoi, Sandy Wan-Heng, Sze, Daniel Man-Yuen, Fung, Kwok-Pui, Leung, Ping-Chung, Lau, Clara Bik-San

Journal:

Chinese Medicine

Année:

2018

Langue:

english

Fichier:

PDF, 7.12 MB

english, 2018

6

Severe acute respiratory syndrome coronavirus ORF3a protein activates the NLRP3 inflammasome by promoting TRAF3-dependent ubiquitination of ASC

Siu, Kam-Leung, Yuen, Kit-San, Castaño-Rodriguez, Carlos, Ye, Zi-Wei, Yeung, Man-Lung, Fung, Sin-Yee, Yuan, Shuofeng, Chan, Chi-Ping, Yuen, Kwok-Yung, Enjuanes, Luis, Jin, Dong-Yan

Journal:

The FASEB Journal

Année:

2019

Langue:

english

Fichier:

PDF, 1.74 MB

english, 2019

7

A tug-of-war between severe acute respiratory syndrome coronavirus 2 and host antiviral defence: lessons from other pathogenic viruses

Fung, Sin-Yee, Yuen, Kit-San, Ye, Zi-Wei, Chan, Chi-Ping, Jin, Dong-Yan

Journal:

Emerging Microbes & Infections

Année:

2020

Langue:

english

Fichier:

PDF, 2.03 MB

english, 2020

8

A machine learning approach for retinal images analysis as an objective screening method for children with autism spectrum disorder

Lai, Maria, Lee, Jack, Chiu, Sally, Charm, Jessie, So, Wing Yee, Yuen, Fung Ping, Kwok, Chloe, Tsoi, Jasmine, Lin, Yuqi, Zee, Benny

Journal:

EClinicalMedicine

Année:

2020

Fichier:

PDF, 522 KB

2020

9

Mannose-binding lectin in chronic hepatitis B virus infection

Wai Po Chong, Yuk Fai To, Wai Kee Ip, Man Fung Yuen, Tung Ping Poon, Wilfred H.S. Wong, Ching Lung Lai, Yu Lung Lau

Journal:

Année:

2005

Langue:

english

Fichier:

PDF, 205 KB

english, 2005

10

Occult hepatitis B infection and HBV replicative activity in patients with cryptogenic cause of hepatocellular carcinoma

Danny Ka Ho Wong, Fung Yu Huang, Ching Lung Lai, Ronnie Tung Ping Poon, Wai Kay Seto, James Fung, Ivan Fan Ngai Hung, Man Fung Yuen

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 217 KB

english, 2011

11

Comparison of the efficacy of lamivudine and famciclovir in Asian patients with chronic hepatitis B: Results of 24 weeks of therapy

Ching-Lung Lai, Man-Fung Yuen, Chee-Kin Hui, Silvia Garrido-Lestache, Charles Tze-Kin Cheng, Yim-Ping Lai

Journal:

Journal of Medical Virology

Année:

2002

Langue:

english

Fichier:

PDF, 71 KB

english, 2002

12

Dosing effects of an antiosteoporosis herbal formula – a preclinical investigation using a rat model

Ye Sun, Simon Ming Yuen Lee, Yin Mei Wong, Ching Po Lau, Pang Chui Shaw, Ling Qin, Ping Chung Leung, Kwok Pui Fung

Journal:

Phytotherapy Research

Année:

2008

Langue:

english

Fichier:

PDF, 112 KB

english, 2008

13

Flexible Ultraviolet Random Lasers Based on Nanoparticles

Shu Ping Lau, Huiying Yang, Siu Fung Yu, Clement Yuen, Eunice S. P. Leong, Hongdong Li, Huey Hoon Hng

Journal:

Année:

2005

Langue:

english

Fichier:

PDF, 135 KB

english, 2005

14

Five-lipoxygenase-activating protein inhibitor MK-886 induces apoptosis in gastric cancer through upregulation of p27kip1 and bax

XIAO MING FAN, SHUI PING TU, SHIU KUM LAM, WEI PING WANG, JING WU, WAI MAN WONG, MAN FUNG YUEN, MARIE CHIA MI LIN, HSIANG FU KUNG, BENJAMIN CHUN-YU WONG

Journal:

Journal of Gastroenterology and Hepatology

Année:

2004

Langue:

english

Fichier:

PDF, 160 KB

english, 2004

15

ABNORMAL WHITENING AND HARDENING OF TRANSFER SET

Sze-Kit Yuen, Siu-Wai Ko, Mei-Ling Wong, Kit-Fung Mok, Yee-Wan Yan, Sai-Ping Yong, Man-Wah Tse

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 167 KB

english, 2010

16

Clinicopathological and prognostic significance of serum and tissue Dickkopf-1 levels in human hepatocellular carcinoma

Edmund Kwok-Kwan Tung, Carmen Ka-Man Mak, Sarwat Fatima, Regina Cheuk-Lam Lo, Heng Zhao, Chunsheng Zhang, Hongyue Dai, Ronnie Tung-Ping Poon, Man-Fung Yuen, Ching-Lung Lai, Jin-jun Li, John Moon-Ching

Journal:

Liver International

Année:

2011

Langue:

english

Fichier:

PDF, 372 KB

english, 2011

17

Long-term follow-up of interferon alfa treatment in chinese patients with chronic hepatitis B infection: The effect on hepatitis B e antigen seroconversion and the development of cirrhosis-related complications

Man-Fung Yuen, Chee-Kin Hui, Chi-Chung Cheng, Chi-Hang Wu, Yim-Ping Lai, Ching-Lung Lai

Journal:

Année:

2001

Langue:

english

Fichier:

PDF, 120 KB

english, 2001

18

A randomized placebo-controlled study of long-acting octreotide for the treatment of advanced hepatocellular carcinoma

Man-Fung Yuen, Ronnie Tung-Ping Poon, Ching-Lung Lai, Sheung-Tat Fan, Chung-Mau Lo, Ka-Wah Wong, Wai Man Wong, Benjamin Chun-Yu Wong

Journal:

Année:

2002

Langue:

english

Fichier:

PDF, 93 KB

english, 2002

19

Non-granulomatous Interstitial Nephritis in a Chinese Man with Sarcoidosis

Sze-Kit Yuen, Chee-Wung Chow, Yat-Wing Lee, Sai-Ping Yong, Mo-Lin Wong, Lin-Kiu Lau, Fung-Yee Siu, King-On Cheung

Journal:

Hong Kong Journal of Nephrology

Année:

2008

Langue:

english

Fichier:

PDF, 320 KB

english, 2008

20

Minimal Change Nephrotic Syndrome with IgM Deposits in Kimura's Disease: A Case Report and Literature Review

Sze-Kit Yuen, Sai-Ping Yong, Wilson Man-Shan Tsui, Fung-Yee Siu, Hing-Sum Tsui, King-On Cheung

Journal:

Hong Kong Journal of Nephrology

Année:

2004

Langue:

english

Fichier:

PDF, 449 KB

english, 2004

21

Quantification of hepatitis B virus covalently closed circular DNA in patients with hepatocellular carcinoma

Danny Ka-Ho Wong, Man-Fung Yuen, Ronnie Tung-Ping Poon, John Chi-Hang Yuen, James Fung, Ching-Lung Lai

Journal:

Journal of Hepatology

Année:

2006

Langue:

english

Fichier:

PDF, 303 KB

english, 2006

22

Polymorphisms of type I interferon receptor 1 promoter and their effects on chronic hepatitis B virus infection

Jie Zhou, Liwei Lu, Man-Fung Yuen, Ting-Wa Lam, Chi-Ping Chung, Chun-Lit Lam, Bin Zhang, Song Wang, Yu Chen, Sharon HW Wu, Vincent KM Poon, Fai Ng, Chris CS Chan, Shibo Jiang, Kwok-Yung Yuen, Bo-Jian

Journal:

Journal of Hepatology

Année:

2007

Langue:

english

Fichier:

PDF, 210 KB

english, 2007

23

The accuracy of SM-HCV rapid test for the detection of antibody to hepatitis C virus

Man-Fung Yuen, Chee-Kin Hui, John Chi-Hang Yuen, John Lap-Ping Young, Ching-Lung Lai

Journal:

American Journal of Gastroenterology

Année:

2001

Langue:

english

Fichier:

PDF, 111 KB

english, 2001

24

Cyclooxygenase-2 inhibitor (SC-236) suppresses activator protein-1 through c-Jun NH2-terminal kinase

Benjamin Chun-yu Wong, Xiao Hua Jiang, Marie C.M. Lin, Shui Ping Tu, Jian Tao Cui, Shi Hu Jiang, Wai Man Wong, Man Fung Yuen, Shiu Kum Lam, Hsiang Fu Kung

Journal:

Gastroenterology

Année:

2004

Langue:

english

Fichier:

PDF, 539 KB

english, 2004

25

Gene therapy for colon cancer by adeno-associated viral vector-mediated transfer of survivin Cys84Ala mutant

Shui Ping Tu, Jian Tao Cui, Peter Liston, Xiao Hua Jiang, Ruian Xu, Marie C.M. Lin, Yan Bo Zhu, Bing Zou, Samuel S.M. Ng, Shi Hu Jiang, Harry H.X. Xia, Wai Man Wong, Annie O.O. Chan, Man Fung Yuen, Sh

Journal:

Gastroenterology

Année:

2005

Langue:

english

Fichier:

PDF, 1.16 MB

english, 2005

26

Fabrication of Covalently Functionalized Graphene Oxide Incorporated Solid-State Hybrid Silica Gel Glasses and Their Improved Nonlinear Optical Response

Tao, Lili, Zhou, Bo, Bai, Gongxun, Wang, Yonggang, Yu, Siu Fung, Lau, Shu Ping, Tsang, Yuen Hong, Yao, Jianquan, Xu, Degang

Journal:

The Journal of Physical Chemistry C

Année:

2013

Langue:

english

Fichier:

PDF, 1.84 MB

english, 2013

27

Hong Kong Renal Registry Report 2012

Ho, Yiu-Wing, Chau, Ka-Foon, Choy, Bo-Ying, Fung, Ka-Sheung, Cheng, Yuk-Lun, Kwan, Tze-Hoi, Wong, Ping-Nam, Lai, Wai-Ming, Yuen, Sze-Kit, Hok-King Lo, Stanley, Chan, Ching-Kit, Leung, Chi-Bon

Journal:

Hong Kong Journal of Nephrology

Année:

2013

Langue:

english

Fichier:

PDF, 6.68 MB

english, 2013

28

Non-alcoholic fatty liver disease and risk of in-stent restenosis after bare metal stenting in native coronary arteries

Shi, Ke-Qing, Wu, Fa-Ling, Liu, Wen-Yue, Zhao, Chen-Chen, Chen, Chang-Xi, Xie, Yao-Yao, Wu, Sheng-Jie, Lin, Xian-Feng, Chen, Yong-Ping, Wong, Danny Ka-Ho, Yuen, Man-Fung, Zheng, Ming-Hua

Journal:

Molecular Biology Reports

Année:

2014

Langue:

english

Fichier:

PDF, 508 KB

english, 2014

29

Increased risk of colorectal malignant neoplasm in patients with nonalcoholic fatty liver disease: a large study

Lin, Xian-Feng, Shi, Ke-Qing, You, Jie, Liu, Wen-Yue, Luo, Ying-Wan, Wu, Fa-Ling, Chen, Yong-Ping, Wong, Danny Ka-Ho, Yuen, Man-Fung, Zheng, Ming-Hua

Journal:

Molecular Biology Reports

Année:

2014

Langue:

english

Fichier:

PDF, 246 KB

english, 2014

30

Preparation and characterization of few-layer MoS 2 nanosheets and their good nonlinear optical responses in the PMMA matrix

Tao, Lili, Long, Hui, Zhou, Bo, Yu, Siu Fung, Lau, Shu Ping, Chai, Yang, Fung, Kin Hung, Tsang, Yuen Hong, Yao, Jianquan, Xu, Degang

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 806 KB

english, 2014

31

The accuracy of SM-HCV rapid test for the detection of antibody to hepatitis C virus

Yuen, Man-Fung, Hui, Chee-Kin, Yuen, John Chi-Hang, Young, John Lap-Ping, Lai, Ching-Lung

Journal:

American Journal of Gastroenterology

Année:

2001

Langue:

english

Fichier:

PDF, 111 KB

english, 2001

32

Chronic black tea extract consumption improves endothelial function in ovariectomized rats

Leung, Fung Ping, Yung, Lai Ming, Ngai, Ching Yuen, Cheang, Wai San, Tian, Xiao Yu, Lau, Chi Wai, Zhang, Yang, Liu, Jian, Chen, Zhen Yu, Bian, Zhao-Xiang, Yao, Xiaoqiang, Huang, Yu

Journal:

European Journal of Nutrition

Année:

2016

Langue:

english

Fichier:

PDF, 1.06 MB

english, 2016

33

Furanodiene induces G2/M cell cycle arrest and apoptosis through MAPK signaling and mitochondria-caspase pathway in human hepatocellular carcinoma cells

Xiao, Yu, Feng-Qing, Yang, Shao-Ping, Li, Jian-Li, Gao, Guang, Hu, Sin-Cheng, Lao, Emilia, Conceição Leong, Kwok-Pui, Fung, Yi-Tao, Wang, Simon, Lee Ming-Yuen

Journal:

Cancer Biology & Therapy

Année:

2007

Langue:

english

Fichier:

PDF, 745 KB

english, 2007

34

Suppression of type I interferon production by human T-cell leukemia virus type 1 oncoprotein Tax through inhibition of IRF3 phosphorylation

Yuen, Chun-Kit, Chan, Ching-Ping, Fung, Sin-Yee, Wang, Pei-Hui, Wong, Wan-Man, Tang, Hei-Man Vincent, Yuen, Kit-San, Chan, Chi-Ping, Jin, Dong-Yan, Kok, Kin-Hang

Journal:

Journal of Virology

Année:

2016

Langue:

english

Fichier:

PDF, 3.92 MB

english, 2016

35

Middle East respiratory syndrome coronavirus M protein suppresses type I interferon expression through the inhibition of TBK1-dependent phosphorylation of IRF3

Lui, Pak-Yin, Wong, Lok-Yin Roy, Fung, Cheuk-Lai, Siu, Kam-Leung, Yeung, Man-Lung, Yuen, Kit-San, Chan, Chi-Ping, Woo, Patrick Chiu-Yat, Yuen, Kwok-Yung, Jin, Dong-Yan

Journal:

Emerging Microbes & Infections

Année:

2016

Langue:

english

Fichier:

PDF, 1.36 MB

english, 2016

36

Hepatitis B virus full-length genomic mutations and quasispecies in hepatocellular carcinoma

Zhang, An-Ye, Lai, Ching-Lung, Poon, Ronnie Tung-Ping, Huang, Fung-Yu, Seto, Wai-Kay, Fung, James, Wong, Danny Ka-Ho, Yuen, Man-Fung

Journal:

Journal of Gastroenterology and Hepatology

Année:

2016

Langue:

english

Fichier:

PDF, 395 KB

english, 2016

37

Gastroesophageal Reflux Disease

Tan, Victoria Ping-Yi, Wong, Benjamin ChunYu, Wong, Wai Man, Leung, Wai Keung, Tong, Daniel, Yuen, Man Fung, Fass, Ronnie

Journal:

Journal of Clinical Gastroenterology

Année:

2016

Langue:

english

Fichier:

PDF, 174 KB

english, 2016

38

Black tea protects against hypertension-associated endothelial dysfunction through alleviation of endoplasmic reticulum stress

San Cheang, Wai, Yuen Ngai, Ching, Yen Tam, Ye, Yu Tian, Xiao, Tak Wong, Wing, Zhang, Yang, Wai Lau, Chi, Chen, Zhen Yu, Bian, Zhao-Xiang, Huang, Yu, Ping Leung, Fung

Journal:

Scientific Reports

Année:

2015

Langue:

english

Fichier:

PDF, 1.38 MB

english, 2015

39

Use of subdural drain for chronic subdural haematoma? A 4-year multi-centre observational study of 302 cases

Chan, David Yuen Chung, Woo, Peter Yat Ming, Mak, Calvin Hoi Kwan, Chu, Alberto Chi Ho, Li, Charles Churk Hang, Ko, Natalie Man Wai, Ng, Stephanie Chi Ping, Sun, Tin Fung David, Poon, Wai Sang

Journal:

Journal of Clinical Neuroscience

Année:

2017

Langue:

english

Fichier:

PDF, 247 KB

english, 2017

40

Global Patterns and Trends of Esophageal Cancer: A Joinpoint Regression Analysis

Chi-Sang Wong, Martin, Jiang, Johnny Yu, Huang, Jason Liwen, Fung, Franklin Dinhei, Wang, Harry Haoxiang, Chen, Ping, Yuan, Xiaoqin, Wu, Yunlin, Wu, Justin Che-yuen

Journal:

Clinical Gastroenterology and Hepatology

Année:

2017

Langue:

english

Fichier:

PDF, 137 KB

english, 2017

41

Interplay between SIRT1 and hepatitis B virus X protein in the activation of viral transcription

Deng, Jian-Jun, Kong, Ka-Yiu Edwin, Gao, Wei-Wei, Tang, Hei-Man Vincent, Chaudhary, Vidyanath, Cheng, Yun, Zhou, Jie, Chan, Chi-Ping, Wong, Danny Ka-Ho, Yuen, Man-Fung, Jin, Dong-Yan

Journal:

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms

Année:

2017

Langue:

english

Fichier:

PDF, 1.55 MB

english, 2017

42

Cryostored autologous skull bone for cranioplasty? A study on cranial bone flaps’ viability and microbial contamination after deep-frozen storage at −80 °C

Chan, David Yuen Chung, Mok, Yi Tan, Lam, Ping Kuen, Tong, Cindy See Wai, Ng, Stephanie Chi Ping, Sun, Tin Fung David, Poon, Wai Sang

Journal:

Journal of Clinical Neuroscience

Année:

2017

Langue:

english

Fichier:

PDF, 222 KB

english, 2017

43

Suppression of Epstein-Barr virus DNA load in latently infected nasopharyngeal carcinoma cells by CRISPR/Cas9

Yuen, Kit-San, Wang, Zhong-Min, Wong, Nok-Hei Mickey, Zhang, Zhi-Qian, Cheng, Tsz-Fung, Lui, Wai-Yin, Chan, Chi-Ping, Jin, Dong-Yan

Journal:

Année:

2017

Langue:

english

Fichier:

PDF, 870 KB

english, 2017

44

Enhanced Photocatalytic Activity of WS2 Film by Laser Drilling to Produce Porous WS2/WO3 Heterostructure

Ma, Sainan, Zeng, Longlui, Tao, Lili, Tang, Chun Yin, Yuan, Huiyu, Long, Hui, Cheng, Ping Kwong, Chai, Yang, Chen, Chuansheng, Fung, Kin Hung, Zhang, Xuming, Lau, Shu Ping, Tsang, Yuen Hong

Journal:

Scientific Reports

Année:

2017

Langue:

english

Fichier:

PDF, 2.09 MB

english, 2017

45

A novel transcript isoform of STING that sequesters cGAMP and dominantly inhibits innate nucleic acid sensing

Wang, Pei-Hui, Fung, Sin-Yee, Gao, Wei-Wei, Deng, Jian-Jun, Cheng, Yun, Chaudhary, Vidyanath, Yuen, Kit-San, Ho, Ting-Hin, Chan, Ching-Ping, Zhang, Yan, Kok, Kin-Hang, Yang, Wanling, Chan, Chi-Ping, J

Journal:

Nucleic Acids Research

Année:

2018

Langue:

english

Fichier:

PDF, 14.62 MB

english, 2018

46

A Phase I, Single- and Multiple-Dose Study to Evaluate the Pharmacokinetics of Elbasvir and Grazoprevir in Healthy Chinese Participants

Cheung, Tommy Tsang, Yan Chiu, Joanne Wing, Yuen, Man Fung, Ling Lam, Karen Siu, Yung Cheung, Bernard Man, Feng, Hwa-Ping, Yeh, Wendy W., Wang, Jiangdian, Li, Wenting, Zhao, Xu Min, Wang, Zaiqi, Mu, S

Journal:

Clinical Therapeutics

Année:

2018

Langue:

english

Fichier:

PDF, 530 KB

english, 2018

47

Genome-Wide Association Study of Hepatocellular Carcinoma in Southern Chinese Patients with Chronic Hepatitis B Virus Infection

Chan, Kelvin Yuen-Kwong, Wong, Chun-Ming, Kwan, Johnny Sheung-Him, Lee, Joyce Man-Fong, Cheung, Ka Wai, Yuen, Man Fung, Lai, Ching Lung, Poon, Ronnie Tung-Ping, Sham, Pak Chung, Ng, Irene Oi-Lin, Tola

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 291 KB

english, 2011

48

Risk Factors and Post-Resection Independent Predictive Score for the Recurrence of Hepatitis B-Related Hepatocellular Carcinoma

Hung, Ivan Fan-Ngai, Wong, Danny Ka-Ho, Poon, Ronnie Tung-Ping, Fong, Daniel Yee-Tak, Chui, Ada Hang-Wai, Seto, Wai-Kay, Fung, James Yan-Yue, Chan, Albert Chi-Yan, Yuen, John Chi-Hang, Tiu, Randal, Ch

Journal:

Année:

2016

Langue:

english

Fichier:

PDF, 1.07 MB

english, 2016

49

Antiviral activity of double-stranded RNA–binding protein PACT against influenza A virus mediated via suppression of viral RNA polymerase

Chan, Chi-Ping, Yuen, Chun-Kit, Cheung, Pak-Hin Hinson, Fung, Sin-Yee, Lui, Pak-Yin, Chen, Honglin, Kok, Kin-Hang, Jin, Dong-Yan

Journal:

The FASEB Journal

Année:

2018

Langue:

english

Fichier:

PDF, 2.23 MB

english, 2018

50

Inhibition of AIM2 inflammasome activation by a novel transcript isoform of IFI16

Wang, Pei‐Hui, Ye, Zi‐Wei, Deng, Jian‐Jun, Siu, Kam‐Leung, Gao, Wei‐Wei, Chaudhary, Vidyanath, Cheng, Yun, Fung, Sin‐Yee, Yuen, Kit‐San, Ho, Ting‐Hin, Chan, Ching‐Ping, Zhang, Yan, Kok, Kin‐Hang, Yang

Journal:

Année:

2018

Langue:

english

Fichier:

PDF, 3.38 MB

english, 2018